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How is essential thrombocytosis treated? Low-dose aspirin therapy (eg, ≤100 mg/day) is acceptable if the ristocetin cofactor level is at least 30% in absence of other high risk factors; if it is less than 30%, all aspirin should be avoided. Hydroxyurea is generally considered the first-line drug for cytoreductive therapy in essential thrombocytosis.
Can hydroxyurea cause leukemia? Hydroxyurea can cause a severe decrease in the number of blood cells in your bone marrow. This may increase the risk that you will develop a serious infection or bleeding. Hydroxyurea may increase the risk that you will develop other cancers, including skin cancer.
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